Spironolactone, an antiandrogenic diuretic, and hair loss are linked through the drug's ability to inhibit dihydrotestosterone (DHT), a potent androgen known to contribute to hair loss. For instance, individuals with conditions that elevate androgen levels, such as polycystic ovary syndrome (PCOS), often experience androgenetic alopecia, a common form of hair thinning.
Spironolactone's mechanism of action makes it a potentially effective treatment for hair loss. It competitively binds to androgen receptors, preventing DHT from binding and exerting its effects on hair follicles. Moreover, spironolactone's anti-inflammatory properties may further protect hair follicles from damage.